• Home / Articulos publicados / Predictors of 1-year mortality after adult lung transplantation: Systematic review and meta-analyses
  • Predictors of 1-year mortality after adult lung transplantation: Systematic review and meta-analyses

17/08/2022

[Artículo]

Los invitamos a leer el siguiente artículo que contó con la participación de la Dr. Juan José Yepes Nuñez

Abstract

Background: Prognostic factors in lung transplantation are those variables that are associated with transplant outcomes. Knowledge of donor and recipient prognostic variables can aid in the optimal allocation of donor lungs to transplant recipients and can also inform post-operative discussions with patients about prognosis. Current research findings related to prognostic factors in lung transplantation are inconsistent and the relative importance of various factors is unclear. This review aims to provide the best possible estimates of the association between putative prognostic variables and 1-year all-cause mortality in adult lung transplant recipients.

Methods: We searched 5 bibliographic databases for studies assessing the associations between putative predictors (related to lung donors, recipients, or the transplant procedure) and 1-year recipient mortality. We pooled data across studies when justified and utilized GRADE methodology to assess the certainty in the evidence.

Results: From 72 eligible studies (2002-2020), there were 34 recipient variables, 4 donor variables, 10 procedural variables, and 7 post-transplant complication variables that were amenable to a meta-analysis. With a high degree of certainty in the evidence only post-transplant need for extra-corporeal membrane oxygenation (ECMO) (HR 1.91, 95% CI 1.79-2.04) predicted 1-year mortality. No donor variables appeared to predict transplant outcome with high or even moderate certainty.

Conclusion: Across the range of contemporary donors and recipients that clinicians accept for lung transplantation, this review, with high certainty, found 1 prognostic factor that predicted 1-year mortality, and 37 additional factors with a moderate degree of certainty. The lack of prognostic significance for some widely accepted factors (e.g., donor smoking, age) likely relates to existing limits in the range of these variables at the time of donor and recipient selection.

Keywords: donor; lung transplant; meta-analysis; mortality; prognosis; recipient; systematic review.

 

 

Noticias Recientes

  • Primeros graduados con el emblema de una gran alianza, Fundación

    Un hito para nuestra facultad

    A partir de ahora el logo de la...

  • ¡Bienvenidos a su alma mater!

    Después de 15 años, la primera generación de médicos de la Facultad de Medicina de la...

  • MediUniandes hace investigación con impacto en salud pública

    Recientemente, nuestro profesor Carlos Valencia (Ph.D en Epidemiología y Salud Pública...

  • Fortaleciendo la educación médica regional con Honduras

    Con el objetivo de estrechar lazos académicos y construir alianzas duraderas,...

  • Carlos Angulo Galvis (1937-2025): El rector que abrió las puerta

    Fue ingeniero civil de la...

  • Convocatoria Estudiante de Maestría en Epidemiología

    ...

  • Convocatoria Profesor/a Instructor/a

    La Facultad de Medicina se complace en anunciar la apertura de una convocatoria...

  • Diana Pachón, egresada de la primera promoción MediUniandes, gan

    La Dra. Diana Pachón, médica egresada de la primera promoción de la Facultad de...

  • Convocatoria | Analista de datos - On the Way to School - EpiAnd

    El grupo de investigación EpiAndes de...

  • Admitidos Posgrados en Epidemiología, Salud Pública y, Bioética

    Bienvenida a los admitidos a nuestros posgrados en Bioética, Epidemiología y Salud...

  • Un encuentro para co-crear, conectar y construir juntos la educa
  • John Mario González elegido representante profesoral ante el con

    El Dr. John Mario González, docente de la Facultad de Medicina, ha sido elegido como...