Los invitamos a leer el siguiente artículo que contó con la participación del Dr. John Mario González y los estudiantes del Laboratorio de Ciencias Básicas.
Objective: To determine whether prepandemic sera from patients with Chagas disease recognize SARS-CoV-2 antigens.
Materials and methods: Forty sera from patients with Chagas disease were tested for the presence of IgG cross-reactivity against the nucleocapsid protein (NP) and spike (S) SARS-CoV-2 proteins by ELISA. Positive samples were tested again using a different ELISA and CLIA, both against NP.
Results: None of the sera from patients with Chagas disease, previously confirmed as positive for the presence of anti-T. cruzi antibodies reacted against the SARS-CoV-2 S protein, and 6 samples tested positive for the NP antigen (15%). The 6 positive samples were re-tested, 5 remained positive by ELISA and all were negative by CLIA.
Conclusion: According to our data, false-positive results might be a concern in the detection of SARS-CoV-2 antibodies in patients with Chagas disease.
Keywords: COVID-19; Chagas disease; SARS-CoV-2; antibody cross-reactivity.
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